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In vivo, 167 improved motor features in MPTP-induced Parkinson’s mice, restored dopamine degrees inside the striatum, and lowered oxidative tension and neuroinflammation by lessening the activation of microglia and astrocytes. The neuroprotective consequences were attained by upregulating antioxidative enzymes for instance SOD2, NRF2, and NQO1, highlighting the probable of 167 as being a therapeutic agent for Parkinson’s disease.

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Structure-action relationship (SAR) scientific tests revealed that aryl groups on the C3 and C6 positions on the indazole core have been important for inhibitory actions.

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